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The author has addressed my concerns. The paper can be published in current form.
Figure 3 is unpublishable in the current form. Please redraw the structures in an acceptable format (as in Table 1).
Radicals are missing on O atoms on the right of Figure 3. Please fix it.
The most important point about the improvement of the chemical part, raised both by reviewer 1 and the editor, has not been addressed. The paper lacks figures and schemes that could help the reader understand the mechanisms through which flavonoids exert their biological effects. More importantly, the author should also add a section focusing on the importance of synthesizing modified compounds/analogues (please provide figures and schemes) to overcome the limits of natural counterparts. In its current form, the work does not fit within the journal's scope and is not acceptable for publication. I suggest the author take the time to make the necessary changes to the manuscript.
I fully agree with Reviewer 1'comments on the improvement of the chemistry part. The author is also encouraged to add a section in which the importance to obtain modified compounds/analogues is discussed (with figures and structures). Structure-activity relationships are also welcome. I think that with these changes the review will be more informative and suitable for a broader readership.
**PeerJ Staff Note:** Please ensure that all review and editorial comments are addressed in a response letter and that any edits or clarifications mentioned in the letter are also inserted into the revised manuscript where appropriate.
**Language Note:** The review process has identified that the English language must be improved. PeerJ can provide language editing services - please contact us at copyediting@peerj.com for pricing (be sure to provide your manuscript number and title). Alternatively, you should make your own arrangements to improve the language quality and provide details in your response letter. – PeerJ Staff
The article is well written and clearly understandable, providing sufficient background in the field.
The study is well designed, but in my opinion it is not fully coherent with the journal scope. I suggest the authors to implement the chemical part
No comments
Please redrawn chemical structures taking into account the correct angle bonding.
a. English is clear enough, but not coherent enough. for example, the sentences in lines 53 and 55 are not coherent
b. The background is quite relevant, but it would be more perfect if it were equipped with references on the mechanism by which flavonoids can increase the quality and production of poultry. Not only as an antioxidant, anti-inflammatory and so on
c. References about flavonoids are still general, specifically in poultry, they are still lacking
d. similar to article: http://dx.doi.org/10.5455/vetworld.2013.573-578
a. according to scope and aim
b. The references used should be more specific
c. The method is detailed
d. References have been paraphrased
e. Library sources have been arranged well
a. The benefits of the literature are clear, but the specific literature on flavonoids in poultry still lacks detail
b. The arguments developed to fulfill the objectives are found in lines 292 and so on
c. The conclusion already states the need for further, more detailed research
A more detailed discussion is needed to make it more informative
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