Wei Xue

Summary

The bioassay results showed that some of the target compounds exhibited fine antibacterial activities against Xac and R.s. Particularly, half maximal effective concentration (EC50) values of some target compounds against R.s are visibly better than that of the positive control bismerthiazol (BT). Notably, compound 4a showed excellent inactivation activity against TMV with a EC50 value of 12.5 μg/mL, which was superior to that of ningnanmycin (NNM,13.5 μg/mL). Besides, molecular docking studies for 4a with tobacco mosaic virus coat protein (TMV-CP) showed that the compound was embedded well in the pocket between the two subunits of TMV-CP. These findings indicate that 1,4-pentadien-3-one derivatives containing triazine moieties may be potential antiviral and antibacterial agents.

Algorithms & Analysis of Algorithms Biomolecules Bioorganic Chemistry Drugs & Devices Green Chemistry Medical Genetics Natural Products Organic Chemistry (other) Organic Compounds Surgery & Surgical Specialties Synthetic Organic Chemistry